Harness the power of the intestinal microbiome with our comprehensive end-to-end analysis solutions for research
With the rapid development of microbiome research in recent years, we now have a deeper understanding of the microbiome’s importance for science and healthcare. However, there are still many associations to be found within the microbiome left to uncover. That’s why we decided to create the ideal solution for all fields of microbiome research and beyond. Our cutting-edge technology and expert team of scientists and researchers are dedicated to advancing the field of microbiome-based diagnostics and improving patient outcomes.
At Biome Diagnostics, we believe that the microbiome holds the key to unlocking new insights and treatments for a wide range of diseases and medical conditions. Through our innovative diagnostic solutions, we aim to empower healthcare professionals and patients alike to take control of their health and well-being.
Our scientific team can guide you on the best way to design an experiment that fits your hypothesis and answers your research questions.
Samples can be collected by the study subjects using an at-home collection kit, containing CE-IVD tubes with a stabilisation fluid.
Microbial DNA is extracted using standardized protocols and the quality is inspected at several steps, ensuring high DNA yield and purity.
16S rRNA gene sequencing provides a broad overview of which bacteria are present in your sample.
The diversity and structure of the microbial communities in your sample are evaluated and the taxonomy is assigned using latest state-of-the-art databases.
The report comprises publication-ready figures and tables that can be directly used to produce manuscripts and share your latest discoveries with the scientific and medical communities.
Cutting-Edge Technology
We utilize the latest advancements in microbiome analysis and sequencing technologies to deliver accurate and comprehensive results. BiomeDx invests in state-of-the-art equipment and employs advanced analytical methodologies, ensuring our clients receive the most up-to-date and reliable information.
Extensive Expertise
We have a wealth of experience in microbiology, genomics, data analysis, and interpretation, enabling us to provide in-depth insights and expert guidance on the results obtained. Our expertise ensures the highest level of accuracy and scientific rigor in our services.
Timely Delivery and Efficiency
We are committed to delivering results in a timely manner, ensuring that clients can make informed decisions or progress with their research without unnecessary delays. We have streamlined our workflows and optimized our processes to maximize efficiency while maintaining the highest quality standards.
Customized Solutions
We understand that microbiome analysis can vary greatly depending on the industry or research focus, and thus we work closely with our clients to design and implement customized approaches that address their unique requirements.
Comprehensive Analytical Capabilities
We can provide a comprehensive profiling of microbial communities, functional analysis, identification of key microbial taxa, and pathway analysis, among other services. This comprehensive approach allows clients to gain a comprehensive understanding of the microbiome under investigation.
Data Privacy and Security
We prioritize data privacy and security, by having robust data protection measures in place, including secure data storage, encryption protocols, and adherence to relevant regulations such as GDPR (General Data Protection Regulation). Clients can trust that their data will be handled with the utmost confidentiality and integrity.
Collaborative Approach
We work closely with clients to understand their goals, provide ongoing support and guidance, and assist with the interpretation and application of the results. This collaborative approach fosters a strong partnership and ensures that clients derive the maximum benefit from their microbiome analysis.
Robust Quality Control Measures
We adhere to standardized protocols, implement rigorous sample handling and processing procedures, and conduct internal quality assessments to ensure accurate and reliable results. Clients can have confidence in the validity of the data generated by BiomeDx.
Ongoing Support
We offer ongoing support before, during or even after the completion of a project, assisting clients with data analysis, interpretation, and any follow-up questions that they might have. This post-project support can be valuable for maximizing the utility of the results and creating publication-grade figures and graphics.
Consultation of experimental design and methods
Collection kit incl. sampling tubes and stool collectors (CE-IVD or non-CE-IVD tubes)
Automated DNA extraction protocol coupled with DNA integrity analysis
16S rRNA sequencing with high read count output
Standard bioinformatics analysis workflow
Data analysis and statistical evaluation
Data transfer of FASTQ files and ASV and functional profiling tables upon request
Study report with associations, statistical significances and graphs
Generation of high-quality figures for publication purposes
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Ongoing collaborations
BioScreen
Lead: Biome Diagnostics, Medical University of Vienna
Funding: Austrian Research Promotion Agency (FFG)
Status: Recruiting participants
Lead: Biome Diagnostics, Medical University of Vienna
Funding: Austrian Research Promotion Agency (FFG)
Status: Recruiting participants
In the BIOSCREEN project we aim to detect a microbial signature for IBS with mucosal biofilms in patient’s stool samples and assess the effect of endoscopic biofilm removal on restoration of microbiome composition and bile acid metabolism. Results from this project will pave the way for non-invasive diagnosis of IBS with or without mucosal biofilms and novel biofilm-targeting therapies extending also to other microbiome driven gastrointestinal diseases.
The intestinal microbiome in acne and rosacea
Lead: Ludwig-Maximilians University Munich, L'Oréal, mybacs, La Roche-Posay, Biome Diagnostics, Newtone
Funding:
Status: Recruiting participants
Lead: Ludwig-Maximilians University Munich, L'Oréal, mybacs, La Roche-Posay, Biome Diagnostics, Newtone
Funding:
Status: Recruiting participants
Interventional, double blind, placebo controlled clinical trial with acne and rosacea patients. Participants will receive oral probiotics and a skin care regime over the course of 16 weeks. At each of four study visits we look at patients’ gut and skin microbiome to investigate changes over time and effects on the clinical severity, which we will document using non-invasive imaging including ColourFace and Skincam.
Recent publications
Demirtas A, Pacífico C, Gruber T, Chizzola R, Zebeli Q, Khiaosa-Ard R. Sigla storax (Liquidambar orientalis) mitigates in vitro methane production without disturbances in rumen microbiota and nutrient fermentation in comparison to monensin. J Appl Microbiol. 2023;134(8):lxad154. doi: 10.1093/jambio/lxad154.
Brezina S, Borkovec M, Baierl A, Bastian F, Futschik A, Gasche N, Gruenberger T, Hallas M, Jannsen C, Leeb G, Lutz R, Sladek B, Gsur A. Using fecal immmunochemical cartridges for gut microbiome analysis within a colorectal cancer screening program. Gut Microbes. 2023;15(1):2176119. doi: 10.1080/19490976.2023.2176119.
Robinson I, Hochmair MJ, Schmidinger M, Absenger G, Pichler M, Nguyen VA, Richtig E, Rainer BM, Ay L, Jansen C, Pacífico C, Knabl A, Sladek B, Gasche N, Valipour A. Assessing the performance of a novel stool-based microbiome test that predicts response to first line immune checkpoint inhibitors in multiple cancer types. Cancers (Basel). 2023;15(13):3268. doi: 10.3390/cancers15133268.
Baumgartner M, Zirnbauer R, Schlager S, Mertens D, Gasche N, Sladek B, Herbold C, Bochkareva O, Emelianenko V, Vogelsang H, Lang M, Klotz A, Moik B, Makristathis A, Berry D, Dabsch S, Khare V, Gasche C. Atypical enteropathogenic E. coli are associated with disease activity in ulcerative colitis. Gut Microbes. 2022;14(1):2143218. doi: 10.1080/19490976.2022.2143218.
Hartinger T, Pacífico C, Poier G, Terler G, Klevenhusen F, Zebeli Q. Shift of dietary carbohydrate source from milk to various solid feeds reshapes the rumen and fecal microbiome in calves. Sci Rep. 2022;12(1):12383. doi: 10.1038/s41598-022-16052-2.
